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Cardiac syndrome X--autonomic system disorders
Władysława Kolasińska-Kloch1, Agata Furgała, Grzegorz Królczyk
1II Klinika Kardiologii Instytut Kardiologii, Collegium Medicum Uniwersytetu Jagiellońskiego.
Folia Medica Cracoviensia
|November 3, 2005
Summary
Cardiac Syndrome X patients often exhibit abnormal autonomic nervous system (ANS) activity, specifically altered sympathetic-parasympathetic balance, impacting heart regulation. This study highlights significant ANS disturbances in a majority of CSX patients.
Area of Science:
- Cardiology
- Autonomic Neuroscience
- Clinical Medicine
Background:
- Abnormal neural regulation of the heart is a key factor in Cardiac Syndrome X (CSX) pathogenesis.
- Understanding autonomic nervous system (ANS) activity is crucial for CSX patient evaluation.
Purpose of the Study:
- To assess autonomic nervous system (ANS) activity changes in patients diagnosed with Cardiac Syndrome X (CSX).
Main Methods:
- Included 42 CSX patients and 42 healthy controls (mean age 46-47 years).
- Evaluated ANS function using non-invasive tests measuring cardiovascular reflexes.
Main Results:
- 50% of CSX patients showed reduced parasympathetic response during deep breathing tests.
- Sympathetic stimulation tests revealed decreased 30/15 ratios in CSX patients.
- Altered cardiac autonomic activities, including parasympathetic withdrawal and sympathetic abnormalities, were observed.
Conclusions:
- CSX patient population is heterogeneous, with approximately 77% displaying abnormal ANS activity.
- Selected ANS tests indicated a disturbed sympathetic-parasympathetic balance in CSX patients.
- Findings emphasize the role of ANS dysfunction in the pathophysiology of CSX.