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Related Experiment Videos

Polypodium leucotomos extract: antioxidant activity and disposition.

L Gombau1, F García, A Lahoz

  • 1Advancell, 46009 Valencia, Spain.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|November 3, 2005
PubMed
Summary

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The fern extract Polypodium leucotomos (PL) contains phenolic compounds that act as potent antioxidants. These compounds are well-absorbed and metabolized, contributing to PL's photoprotective health benefits.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Dermatology

Background:

  • Polypodium leucotomos (PL) extract is an oral photoprotectant with known antioxidant properties.
  • Key phenolic components include p-coumaric, ferulic, caffeic, vanillic, and chlorogenic acids.
  • Data on the H2O2-scavenging capacity, absorption, and metabolism of these PL components are limited.

Purpose of the Study:

  • To assess the H2O2-scavenging capacity of major phenolic components of PL.
  • To investigate the absorption and metabolism of these compounds after oral intake.
  • To correlate these properties with the photoprotective effects of PL.

Main Methods:

  • Antioxidant capacity was measured using the luminol/H2O2 assay.
  • Absorption was studied in vitro using Caco-2 cell monolayers.

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  • Metabolism was investigated in cultured primary rat hepatocytes.

    • Main Results:

    • Antioxidant capacity increased with concentration; ferulic and caffeic acids showed the highest potency.
    • Apparent permeability indicated 70-100% absorption in humans post-oral administration.
    • Coumaric, ferulic, and vanillic acids underwent CYP450 metabolism and partial conjugation.

    Conclusions:

    • The phenolic constituents of PL exhibit significant antioxidant activity and good oral absorption.
    • Metabolism involves CYP450 enzymes and conjugation pathways.
    • These properties support the role of these compounds in the health benefits of oral photoprotection by PL.