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Updated: Aug 15, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Enzymes in the biosynthesis of aromatic polyketide antibiotics
1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheele's väg 2, S-17177 Stockholm, Sweden. gunter.schneider@mbb.ki.se
Abstract:
Aromatic polyketides are secondary metabolites that afford some of the most common antibiotics and anti-cancer drugs currently in clinical use. Not least because of their medical importance, the biosynthesis of these compounds has attracted considerable interest during the past few years; important advances have been made in the structural and mechanistic characterisation of the enzymes involved. These studies are expected to have implications for the production of novel therapeutic agents by combinatorial biosynthesis.
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