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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
Published on: November 5, 2014
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function
Robert J Chambers1, Kristin Abrams, Tessa A Castleberry
1Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Robert.J.Chambers@pfizer.com
Bioorganic & Medicinal Chemistry Letters
|November 3, 2005
Abstract:
Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
