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Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes
Keli Gu1, Lanrong Bi, Ming Zhao
1College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, PR China.
Abstract:
A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships.
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