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Updated: Aug 15, 2026
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Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
Published on: January 31, 2025
The kidney, cancer, and the eye: current concepts
1The New York Eye Cancer Center, and the New York University School of Medicine, New York, NY 10021, USA.
Survey of Ophthalmology
|November 3, 2005
Summary
Ophthalmologists play a crucial role in detecting kidney cancers by recognizing eye metastases and ocular anomalies. Early diagnosis and treatment of renal tumors and associated eye conditions improve patient outcomes.
Area of Science:
- Ophthalmology
- Nephrology
- Oncology
Background:
- Renal cancers can metastasize to the eye and orbit, mimicking other tumors.
- Ocular anomalies are frequently associated with renal diseases, including Wilms tumor.
- Paraneoplastic syndromes and cancer syndromes can link kidney and eye pathologies.
Purpose of the Study:
- To review the associations between the kidney, renal cancers, and the eye.
- To highlight the importance of ophthalmologists in diagnosing and managing renal-associated diseases.
- To discuss the clinical features, management, and screening of these conditions.
Main Methods:
- Literature review of studies on renal cancer metastasis to the eye.
- Analysis of ocular manifestations of renal diseases and cancer syndromes.
- Discussion of diagnostic challenges and therapeutic strategies.
Main Results:
- Renal tumors can present with ocular metastases requiring high suspicion for early detection.
- Wilms tumor may present with aniridia, aiding in early diagnosis.
- Paraneoplastic retinopathies and neuro-ophthalmic disorders are linked to renal cancers.
- Von Hippel tumors indicate potential associated visceral tumors.
- Systemic treatments for renal tumors can cause ocular side effects.
Conclusions:
- Ophthalmologists are essential for the early diagnosis and treatment of kidney tumors and associated eye conditions.
- Prompt ophthalmic examinations are vital for patients undergoing treatment for renal tumors.
- Integrated care can reduce morbidity and mortality in patients with kidney and eye-related diseases.
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