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Chronic lung disease after hematopoietic stem cell transplantation
Bekele Afessa1, Steve G Peters
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Clinics in Chest Medicine
|November 3, 2005
Summary
Hematopoietic stem cell transplantation (HSCT) can lead to serious lung problems. This review focuses on the noninfectious, chronic pulmonary complications that affect HSCT patients.
Area of Science:
- Medicine
- Pulmonology
- Hematology
Background:
- Hematopoietic stem cell transplantation (HSCT) is a common treatment for hematologic disorders.
- Patients undergoing HSCT face risks of multi-organ damage from therapies like chemotherapy and radiation.
- Pulmonary complications affect a significant portion (30-60%) of HSCT recipients.
Purpose of the Study:
- To review the noninfectious, chronic pulmonary complications following HSCT.
- To highlight the shift in pulmonary complication spectrum from infectious to noninfectious causes.
Main Methods:
- Literature review of noninfectious, chronic pulmonary complications after HSCT.
Main Results:
- Pulmonary complications are frequent after HSCT.
- Infectious pulmonary complications have decreased due to prophylaxis.
- Noninfectious pulmonary complications are now a more prominent concern.
Conclusions:
- Noninfectious pulmonary complications are a significant issue for HSCT survivors.
- Understanding these chronic lung issues is crucial for patient management post-transplant.
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