Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ZAP-70 in B cell malignancies.

Jenny Orchard1, Rachel Ibbotson, Giles Best

  • 1Department of Haematology, Royal Bournemouth Hospital, UK.

Leukemia & Lymphoma
|November 3, 2005
PubMed
Summary

ZAP-70, a protein tyrosine kinase (PTK), shows prognostic importance in chronic lymphocytic leukemia (CLL). Its presence correlates with poorer prognosis in unmutated CLL, while absence suggests a better outlook in mutated CLL.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Australasian chronic lymphocytic leukaemia consensus statement: 2026 update.

Internal medicine journal·2026
Same author

USP2 is an androgen-repressed survival factor that stabilises oncoproteins to facilitate therapy resistance in prostate cancer.

Cell death & disease·2026
Same author

HDL-Functionalized Biomaterial Coatings Provide Favorable Immunomodulation and Enhance Osteogenesis.

ACS applied materials & interfaces·2026
Same author

A matter of age: Investigation of the ability to classify epithelial cells of different anatomical origin in aged samples using imaging flow cytometry.

Forensic science international·2026
Same author

Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.

Leukemia·2025
Same author

Novel Molecular Signatures of Peripheral Regulatory T Cells in Kidney Disease Associated with Type 1 Diabetes.

Kidney360·2025

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • ZAP-70 (protein tyrosine kinase) is crucial in T and NK cell signaling.
  • ZAP-70 is absent in normal peripheral B cells but expressed in certain B cell malignancies.
  • Gene expression profiling identified ZAP-70 as a potential prognostic marker in chronic lymphocytic leukemia (CLL).

Purpose of the Study:

  • To evaluate the prognostic significance of ZAP-70 expression in chronic lymphocytic leukemia (CLL).
  • To investigate the correlation between ZAP-70 expression and IgVH gene mutational status in CLL.
  • To review the challenges and current status of ZAP-70 as a prognostic marker in CLL.

Main Methods:

  • Gene expression profiling comparing unmutated and mutated IgVH gene subsets in CLL.
  • Analysis of ZAP-70 expression in CLL patient samples.
  • Review of existing literature on ZAP-70 function and measurement in B cell malignancies.

Main Results:

  • ZAP-70 is expressed in the majority of poorer prognosis unmutated CLL cases.
  • ZAP-70 is absent in most mutated IgVH gene CLL cases, indicating better prognosis.
  • ZAP-70 is functionally important in CLL cases where it is expressed.

Conclusions:

  • ZAP-70 expression is a significant prognostic indicator in CLL, differentiating between high-risk (unmutated IgVH) and low-risk (mutated IgVH) disease.
  • Further standardization of ZAP-70 measurement is needed for its reliable clinical application.
  • ZAP-70's role in CLL pathogenesis, whether reflecting cell activation or maturation stage, requires further investigation.

Related Experiment Videos