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Updated: Aug 15, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Allergic colitis presenting within the first hours of premature life

Marianne R Faber1, Paul Rieu, Ben A Semmekrot

  • 1Department of Paediatrics, University Medical Centre, St Radboud, Nijmegen, The Netherlands.

Acta Paediatrica (Oslo, Norway : 1992)
|November 3, 2005
PubMed

Insights

Cow's milk-induced allergic colitis can manifest in premature infants shortly after birth, even after the first feeding. This condition, possibly due to intrauterine sensitization, requires consideration in diagnosing rectal blood loss in neonates.

Area of Science:

  • Neonatal Medicine
  • Allergology
  • Gastroenterology

Background:

  • Cow's milk allergy is a common concern in infants.
  • Rectal blood loss in neonates necessitates a thorough differential diagnosis.

Observation:

  • A premature infant presented with rectal blood loss hours after initial formula feeding.
  • Symptoms resolved upon feeding cessation and recurred upon reintroduction.
  • Necrotizing enterocolitis was ruled out.

Findings:

  • Initial trials with casein-based protein hydrolysate were ineffective.
  • Laboratory tests confirmed cow's milk allergy.
  • Symptoms resolved exclusively with an amino acid-based formula, confirming cow's milk-induced allergic colitis.

Implications:

  • This case highlights cow's milk-induced allergic colitis in a premature infant presenting within hours of birth.
  • Intrauterine sensitization is a likely mechanism, though further research is needed.
  • Cow's milk-induced allergic colitis should be considered in the differential diagnosis of neonatal rectal bleeding.
Abstract

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