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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Survival and death causes in differentiated thyroid carcinoma
Carmen F A Eustatia-Rutten1, Eleonora P M Corssmit, Nienke R Biermasz
1Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
The Journal of Clinical Endocrinology and Metabolism
|November 3, 2005
Summary
Differentiated thyroid carcinoma (DTC) patients with advanced stage (T4), distant metastases, or older age face higher mortality risks. Even early-stage DTC contributes significantly to overall death rates in these patients.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Differentiated thyroid carcinoma (DTC) survival studies often lack homogeneity, potentially biasing results.
- Specific causes of death in DTC patients are not well-documented in existing literature.
Purpose of the Study:
- To investigate survival outcomes and specific causes of death in a homogeneous cohort of DTC patients.
- To identify prognostic factors associated with DTC-related mortality.
Main Methods:
- Analysis of 366 consecutive DTC patients treated under a unified protocol.
- Univariate and multivariate Cox regression analyses to identify risk factors for DTC-related death.
- Calculation of standardized mortality ratios (SMR) using Dutch population data.
Main Results:
- During 8.3 years of follow-up, 82 patients (22.4%) died.
- Advanced tumor stage (T4), distant metastases, and older age were linked to increased DTC-related death risk.
- Overall SMR was 2.32, elevated in patients with T4 stage, metastases, or advanced age.
Conclusions:
- Patients with stage T4, distant metastases (M1), or advanced age have significantly higher risks of thyroid cancer-related death and SMR.
- While T1-3 M0 patients do not have increased death risk, DTC remains a significant contributor to mortality across all patient categories.
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