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Updated: Aug 15, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Oral squamous cell carcinoma. Cytometric parameters of prognostic interest
Ramón Saiz-Bustillo1, Guadalupe Corchero-Martín, Belén García-Montesinos-Perea
1Servicio de Cirugía Oral y Maxilofacial, Hospital Universitario Marqués de Valdecilla, Santander. guacorch@yahoo.es
Objectives:
The present study was made in order to find possible prognostic factors in oral squamous cell carcinoma, given that it is a frequent disease (3-4% of all malignant tumors) and is the cause of a high morbidity and mortality which justifies any attempt to contribute something towards the understanding of this pathology.
Study Design:
81 oral squamous cell carcinomas, treated with the same procedure, and retrieved from the archive of the Hospital Universitario Marqués de Valdecilla (Santander) were studied. Flow cytometry was carried out on 67 of the samples.
Results:
No statistically significant differences were found between the cellular proliferative index and the mitotic index, ploidy and the S-phase factor. Likewise, none of the cytometric variables studied presented any association with the appearance of local relapse, distant metastases or survival.
Conclusions:
These variables cannot be used as a prognostic factors in squamous cell carcinomas of the oral cavity.
