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Controlled-release doxazosin in the treatment of benign prostatic hyperplasia
1Hospital General Universitario Gregorio Marañón, Madrid, Spain. chdez@pulso.com
Purpose:
To evaluate the effectiveness and safety of controlled-release doxazosin for benign prostatic hyperplasia (BPH).
Scope:
In this open-label, noncontrolled, observational surveillance study, 3684 men with BPH received 4-8 mg of controlled-release doxazosin gastrointestinal therapeutic system (GITS) for 6 months; 3283 (89.1%) patients completed the trial. Changes in urinary symptoms and quality of life were assessed using the International Prostate Symptom Score (IPSS). Blood pressure and adverse events were assessed.
Conclusion:
After 6 months' treatment with doxazosin GITS resulted in significant improvements in IPSS. BP was reduced only in hypertensive patients. Doxazosin, GITS was well tolerated.
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