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Related Experiment Videos

Baroreceptor reflex function in congestive heart failure.

M A Creager1

  • 1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

The American Journal of Cardiology
|June 4, 1992
PubMed
Summary
This summary is machine-generated.

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Baroreceptor reflex function is impaired in heart failure, leading to reduced responses to changes in blood pressure. This dysfunction contributes to the altered autonomic nervous system activity seen in heart failure patients.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation

Background:

  • Congestive heart failure (CHF) involves altered autonomic nervous system (ANS) activity, with decreased parasympathetic and increased sympathetic tone.
  • Baroreceptor reflex dysfunction is a potential contributor to these ANS changes in CHF.

Purpose of the Study:

  • To investigate the role of cardiopulmonary and arterial baroreceptor reflex function in the pathophysiology of heart failure.
  • To compare baroreceptor reflex responses in experimental models and human patients with heart failure to healthy controls.

Main Methods:

  • Assessed afferent neural activity in response to baroreceptor stimulation in experimental heart failure models.
  • Measured heart rate and blood pressure responses to baroreceptor pressure perturbations (e.g., lower-body negative pressure, neck chamber) in animals and humans with heart failure.

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Main Results:

  • Baroreceptor reflex stimulation showed reduced effects on neural activity in heart failure models.
  • Heart rate and blood pressure responses to baroreceptor pressure changes were attenuated in animals and humans with heart failure compared to controls.
  • Lower-body negative pressure resulted in less forearm vasoconstriction in heart failure patients.

Conclusions:

  • Abnormalities in cardiopulmonary and arterial baroreceptor reflex function are significant in heart failure.
  • Impaired baroreceptor reflex contributes to the altered autonomic nervous system activity characteristic of congestive heart failure.