Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methods for trend estimation from summarized dose-response data, with applications to meta-analysis.

S Greenland1, M P Longnecker

  • 1Department of Epidemiology, School of Public Health, University of California, Los Angeles.

American Journal of Epidemiology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative bias analysis of the association of type 2 diabetes mellitus with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153).

Environment international·2019
Same author

Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort.

Environment international·2019
Same author

Hormonal contraceptive use before and after conception in relation to preterm birth and small for gestational age: an observational cohort study.

BJOG : an international journal of obstetrics and gynaecology·2014
Same author

Maternal hormonal contraceptive use and offspring overweight or obesity.

International journal of obesity (2005)·2014
Same author

The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling.

Environmental research·2013
Same author

Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.

Diabetologia·2013
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
Same journal

Maternal Cesarean Section and Offspring ASD or ADHD Risk: A Nurses' Health Study II Analysis.

American journal of epidemiology·2026
See all related articles

Researchers developed new meta-analysis methods to accurately pool correlated data for estimating trends. These techniques improve regression slope and variance estimation, offering more valid heterogeneity tests and enabling nonlinear trend analysis.

Area of Science:

  • Biostatistics
  • Epidemiology
  • Public Health

Background:

  • Meta-analysis commonly pools study estimates to determine trends.
  • Existing methods struggle with correlated estimates, leading to less accurate results.
  • Accurate trend estimation is crucial for understanding exposure-response relationships.

Purpose of the Study:

  • To introduce novel meta-analysis methods for handling correlated estimates.
  • To enhance the efficiency and accuracy of regression slope and variance estimation.
  • To enable more robust heterogeneity testing and nonlinear trend analysis.

Main Methods:

  • Proposed two statistical methods for meta-analysis incorporating correlated estimates.
  • Required only summary estimates and marginal data from individual studies.

Related Experiment Videos

  • One method extended to estimate nonlinear trend components, like quadratic effects.

    • Main Results:

    • The new methods provide more efficient regression slope estimates.
    • Variance estimates are more accurate compared to previous approaches.
    • Heterogeneity tests are more valid, improving overall meta-analysis reliability.

    Conclusions:

    • The developed methods offer significant improvements for meta-analyses with correlated data.
    • These techniques enhance the precision of trend estimation and heterogeneity assessment.
    • Applicable to various fields, including environmental health and clinical research, as shown in alcohol-breast cancer analysis.