Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early monoaminergic dysfunction.

Y Takeuchi1, T Sawada, P Jenner

  • 1Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.

Brain & Development
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism.

Pharmacology, biochemistry, and behavior·2003
Same author

Inhibition of neuronal nitric oxide synthase increases dopamine efflux from rat striatum.

Journal of neural transmission (Vienna, Austria : 1996)·2003
Same author

Commonly used L-amino acid decarboxylase inhibitors block monoamine oxidase activity in the rat.

Journal of neural transmission (Vienna, Austria : 1996)·2003
Same author

Alterations in striatal neuropeptide mRNA produced by repeated administration of L-DOPA, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets.

Neuroscience·2002
Same author

Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets.

Neuroscience·2002
Same author

The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration.

Journal of neural transmission (Vienna, Austria : 1996)·2002
Same journal

From weather stations to the home environment: Refining seizure prediction in pediatric drug-resistant epilepsy.

Brain & development·2026
Same journal

Pediatric GBS-myelitis overlap syndrome: Severe phenotype, treatment response, and neurological outcomes.

Brain & development·2026
Same journal

Aspartoacylase (ASPA) gene mutations and neuroimaging features in Iranian patients with Canavan disease: a descriptive study.

Brain & development·2026
Same journal

Third nationwide survey of bilirubin encephalopathy in preterm infants in Japan.

Brain & development·2026
Same journal

Urine protein/osmolality and creatinine/osmolality ratios for assessing proteinuria and motor function in children with spinal muscular atrophy.

Brain & development·2026
Same journal

Periodic limb movements during sleep in Lesch-Nyhan syndrome.

Brain & development·2026
See all related articles

Early monoaminergic dysfunction is implicated in Rett syndrome. Understanding regional and age-dependent vulnerabilities, along with neural interactions, is crucial for assessing monoamine neuron system alterations in this condition.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Rett syndrome is a complex neurodevelopmental disorder.
  • Monoamine systems play a critical role in brain development and function.
  • Evidence suggests a link between monoaminergic dysfunction and Rett syndrome pathogenesis.

Purpose of the Study:

  • To review the chemical anatomy of Rett syndrome.
  • To examine experimental studies on early monoaminergic lesions in the context of Rett syndrome.
  • To identify key factors for assessing alterations in the monoamine neuron system.

Main Methods:

  • Literature review of chemical anatomy in Rett syndrome.
  • Analysis of experimental studies on early monoaminergic lesions.
  • Synthesis of findings regarding monoamine neuron system alterations.

Related Experiment Videos

Main Results:

  • Early monoaminergic dysfunction is a probable mechanism underlying Rett syndrome.
  • Specific vulnerabilities within the monoamine neuron system are observed.
  • Age-dependent changes in monoamine systems are relevant to Rett syndrome.

Conclusions:

  • Monoaminergic dysfunction is a key feature in Rett syndrome.
  • Assessing alterations requires consideration of regional vulnerability.
  • Age-dependent vulnerability and inter-system interactions are critical factors.