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[Hereditary colorectal cancer].

Inge T Bernstein1, Steffen Bülow

  • 1H:S Hvidovre Hospital, Gastroenheden 435, HNPCC-registret og Polyposeregistret, Hvidovre. inge.bernstein@hh.hosp.dk

Ugeskrift for Laeger
|November 4, 2005
PubMed
Summary
This summary is machine-generated.

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Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2019

Hereditary non-polyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) significantly increase colorectal cancer (CRC) risk. Early screening and central registration improve outcomes for these inherited conditions.

Area of Science:

  • Genetics and Oncology
  • Hereditary Cancer Syndromes

Context:

  • Familial Adenomatous Polyposis (FAP) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC) are inherited conditions.
  • These syndromes carry a high lifetime risk (80-100%) of colorectal cancer (CRC).
  • Mutations in APC (FAP) and Mismatch Repair (MMR) genes (HNPCC) are identified causes.

Purpose:

  • To evaluate the impact of screening and management strategies on colorectal cancer (CRC) in FAP and HNPCC patients.
  • To highlight the importance of early detection and continuous registration for high-risk families.

Summary:

  • Screening in FAP patients reduced CRC prevalence by 55% and improved survival.
  • In HNPCC, screening detected 77% of CRCs at early stages (Duke's A or B), significantly improving survival since 1990.

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  • Centralized registration in HNPCC and Polyposis registers is recommended for identifying high-risk families and assessing screening effectiveness.

    • Impact:

    • Screening programs have demonstrably reduced CRC prevalence and improved survival rates in FAP and HNPCC.
    • Early detection through screening leads to better prognoses for individuals with these hereditary cancer syndromes.
    • Centralized registries are crucial for long-term management and research of hereditary CRC.