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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Seven-transmembrane receptor signaling through beta-arrestin

Sudha K Shenoy1, Robert J Lefkowitz

  • 1Howard Hughes Medical Institute, Durham, NC 27710, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|November 4, 2005
PubMed
Summary

Beta-arrestins, initially known for desensitizing seven-transmembrane receptors (7TMRs), are now recognized as key signaling adaptors. They mediate receptor internalization and regulate diverse cellular responses via pathways like MAPK signaling.

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