Conserved prefusion protein assembly in regulated exocytosis

Colin Rickman1, José L Jiménez, Margaret E Graham

  • 1MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom.

Summary

Regulated secretion relies on a pre-assembled protein scaffold. Synaptotagmin and SNARE proteins form a "tethering" structure before calcium signals, ensuring precise hormone and neurotransmitter release.

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