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Related Experiment Videos

Delayed hypersensitivity to diltiazem in two patients.

A Romano1, F Pietrantonio, A Garcovich

  • 1Istituto di Clinica Medica, Università Cattolica del S. Cuore, Rome, Italy.

Annals of Allergy
|July 1, 1992
PubMed
Summary

Two patients experienced severe skin reactions, including widespread rashes and facial swelling, after starting diltiazem. Delayed hypersensitivity to diltiazem was confirmed through patch testing and biopsy.

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Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Diltiazem is a widely prescribed calcium channel blocker for cardiovascular conditions.
  • Cutaneous adverse drug reactions (CADRs) are common but can vary significantly in presentation.

Observation:

  • Two patients developed severe, widespread, itchy, red, maculopapular eruptions with fever and facial angioedema.
  • These reactions occurred 48-72 hours after initiating diltiazem therapy.

Findings:

  • Delayed hypersensitivity to diltiazem was suspected as the cause of the adverse reactions.
  • Diagnosis was confirmed by positive skin patch tests and subsequent skin biopsy.

Implications:

  • This case series highlights the potential for diltiazem to cause severe delayed hypersensitivity reactions.

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  • Clinicians should consider diltiazem-induced hypersensitivity in patients presenting with similar cutaneous reactions.
  • Diagnostic confirmation via patch testing and biopsy is crucial for accurate diagnosis and management.