Related Experiment Video
Updated: Aug 1, 2026

08:06
The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
A novel azetidinyl gamma-lactam based peptide with a preference for beta-turn conformation
Amit Basak1, Subhash C Ghosh, Amit K Das
1Bioorganic Chemistry Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India.
Organic & Biomolecular Chemistry
|November 4, 2005
Abstract:
Novel azetidinyl gamma-lactam based peptides have been synthesized with only compound showing a preference for the beta-turn conformation.
Related Concept Videos
Peptidoglycan Synthesis
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
Inhibitors of Gram-positive Cell Wall Synthesis
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...

