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Related Experiment Videos

Myeloid leukemias and lung involvement.

Tat Tee Koh1, Thomas V Colby, Nestor L Müller

  • 1Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

Seminars in Respiratory and Critical Care Medicine
|November 4, 2005
PubMed
Summary

Pulmonary involvement in myeloid leukemias is uncommon, primarily affecting severe cases. This review details the histological and radiological signs of intrathoracic manifestations in myelogenous leukemias.

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Area of Science:

  • Hematology
  • Pulmonology
  • Radiology

Background:

  • Myeloid leukemias are clonal malignancies involving myeloid cell proliferation.
  • Pulmonary involvement in myeloid leukemia is infrequent, typically observed in severe disease stages.

Purpose of the Study:

  • To review the histological and radiological intrathoracic manifestations of myelogenous leukemias.
  • To describe common and less common forms of pulmonary involvement in myeloid leukemia.

Main Methods:

  • Review of histological findings in pulmonary myeloid leukemia.
  • Analysis of radiological features associated with pulmonary myeloid leukemia.

Main Results:

  • The most frequent pulmonary manifestation is leukemic infiltration along lymphatics, causing interstitial thickening.

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  • Less common forms include myeloid sarcoma, leukostasis, leukemic cell lysis pneumopathy, and hyperleukocytic reaction.
  • Radiological patterns include interstitial thickening resembling pulmonary edema and symmetric consolidation.

    • Conclusions:

    • Understanding the diverse intrathoracic manifestations is crucial for diagnosing and managing pulmonary involvement in myeloid leukemias.
    • Radiological findings can suggest specific types of pulmonary leukemic involvement, guiding further investigation.