[Pathological aspects of the prolonged forms of the hepatitis "A"]

Prolonged forms of the hepatitis "A" have been examined during the three year multicentric prospected study.

Of the study from patohistological aspect was: 1) Determinate stage and type of liver damage during the differentiate phase of prolonged HAV infection; 2) The resultats of the researches compared with duration of persistance activity of serum ALT, circulating immune complexes (CIC) and persistence length IgM anti-HAV.

In 21 patients with prolonged Hepatitis "A" have been done Biopsy of Liver with Menhginy needle by intercostal approach. We put the material into formalin and it was processed by standard procedure. Biopsy of liver was preformed between 50-60 days, 60-180 days, 180-210 days of illness. Anti-HAV IgM was determined by ELISE method. CIC have determined photometrically in the poliethylenglycole sediment.

of the researches showed that in 21 patients with biopsy Hepatitis acuta was faund in 20%, 55 % residue posthepatitis, 10% patients had nonspecifical finding, 10 % reported hronical persistence hepatitis and 5% chronical active hepatitis.

Authors conclused that during the prolonged HAV infection, all stages of liver damage can be find from acute to chronic illness. There is positive correlation between persistance of maintaince of CiC and IgM anti-HAV in patients sera and staging of patohistological lesions in liver. There is no correlation between activity of CIC, activity ALT in sera and study of liver lesions.