Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic predisposition to cancer.

Clare Turnbull1, Shirley Hodgson

  • 1Clinical Genetics, Great Ormond Street Hospital, London. turnbc@gosh.nhs.uk

Clinical Medicine (London, England)
|November 5, 2005
PubMed
Summary

Genetic predisposition to cancer involves both rare high-penetrance genes and common lower-penetrance genes interacting with environmental factors. Identifying at-risk individuals is crucial for timely interventions like genetic testing and surveillance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer Variant Interpretation Group UK (CanVIG-UK): updates on an exemplar national subspecialty multidisciplinary network.

Journal of medical genetics·2026
Same author

Combining multiplexed functional data to improve variant classification.

Genome medicine·2026
Same author

Routine germline genetic testing in 3552 unselected NHS breast cancer patients: evidence informing testing criteria and implementation of a 'BRCA-DIRECT' mainstreaming pathway.

NPJ breast cancer·2026
Same author

Interpretation of Survival Outcomes in Multicancer Early Detection Testing Requires Caution.

JCO precision oncology·2026
Same author

Science Outreach: Providing an Authentic Independent Research Opportunity in Materials Science to School Students.

Journal of chemical education·2026
Same author

Contralateral breast cancer risks for BRCA1, BRCA2, PALB2, CHEK2, and ATM pathogenic variant carriers in two large cohort studies.

BJC reports·2026

Area of Science:

  • Genetics
  • Oncology
  • Preventive Medicine

Background:

  • Numerous cancer predisposition genes have been identified over recent decades.
  • Cancer predisposition can stem from rare autosomal dominant monogenic syndromes or multifactorial etiologies involving lower-penetrance genes and environmental factors.
  • Family history is a key indicator of increased cancer risk.

Purpose of the Study:

  • To examine the issues surrounding genetic predisposition to cancer.
  • To highlight the importance of identifying individuals at increased risk.
  • To discuss implications for common cancers, specifically colorectal and breast cancer.

Main Methods:

  • Review of scientific literature on genetic predisposition to cancer.
  • Focus on two common cancer types: colorectal and breast cancer.
  • Discussion of diagnostic and management strategies.

Main Results:

  • Cancer predisposition is complex, involving both single genes and multiple factors.
  • Identification of genetic risk enables personalized cancer prevention strategies.
  • Genetic testing, enhanced surveillance, and prophylactic measures are key interventions.

Conclusions:

  • Understanding genetic predisposition is vital for effective cancer risk management.
  • Multifactorial etiology necessitates a comprehensive approach to risk assessment.
  • Early identification of at-risk individuals can significantly impact cancer outcomes.

Related Experiment Videos