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Related Concept Videos

Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Transplantation proteomics.

Avram Z Traum1, Asher D Schachter

  • 1Division of Nephrology, Children's Hospital Boston, MA, USA.

Pediatric Transplantation
|November 5, 2005
PubMed
Summary
This summary is machine-generated.

Translational proteomics uses advanced methods to study protein expression for predicting clinical outcomes in transplantation. This review covers proteomics techniques and informatics for non-invasive urine analysis in transplant research.

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Area of Science:

  • Proteomics
  • Translational research
  • Clinical transplantation

Background:

  • The proteome is dynamic and complex, influenced by post-translational modifications.
  • Understanding proteomics methods and limitations is crucial for translational investigators.
  • Genomic and transcriptomic data complement proteomic insights.

Purpose of the Study:

  • To provide an overview of proteomics approaches and informatics for clinical transplantation.
  • To review recent publications in transplantation proteomics.
  • To discuss the utility of urine proteomics for non-invasive transplant outcome assessment.

Main Methods:

  • Review of established and emerging proteomics technologies.
  • Analysis of proteomics informatics tools.
  • Literature review of recent transplantation proteomics studies.

Main Results:

  • Proteomics offers predictive insights into clinical events and therapeutic responses.
  • Urine proteomics presents a promising avenue for non-invasive monitoring of transplant recipients.
  • Challenges in proteomics include proteome dynamism and post-translational modifications.

Conclusions:

  • Translational proteomics is vital for advancing clinical transplantation.
  • Standardized proteomics approaches and informatics are needed.
  • Urine proteomics holds significant potential for non-invasive transplant monitoring.