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Related Concept Videos

Endoplasmic Reticulum01:39

Endoplasmic Reticulum

119.3K
The Endoplasmic Reticulum (ER) in eukaryotic cells is a substantial network of interconnected membranes with diverse functions, from calcium storage to biomolecule synthesis. A primary component of the endomembrane system, the ER manufactures phospholipids critical for membrane function throughout the cell. Additionally, the two distinct regions of the ER specialize in the manufacture of specific lipids and proteins.
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Golgi Apparatus01:49

Golgi Apparatus

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As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
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Golgi Apparatus01:09

Golgi Apparatus

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Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
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The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

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The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
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Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

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Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
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The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

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No description available
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Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
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Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells

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An E-MAP of the ER.

Elizabeth Conibear1

  • 1Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver V5Z 4H4, Canada.

Cell
|November 5, 2005
PubMed
Summary
This summary is machine-generated.

Saturation epistasis analysis reveals functional gene relationships. This high-throughput genomic data strategy uncovers gene function in the yeast secretory pathway.

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Area of Science:

  • Genomics
  • Systems Biology
  • Molecular Biology

Background:

  • Genome-wide phenotype mapping offers insights into gene function.
  • Understanding gene interactions is crucial for biological research.

Purpose of the Study:

  • To develop a new strategy for uncovering functional relationships between genes.
  • To apply high-throughput genomic data analysis to yeast genetics.

Main Methods:

  • Saturation epistasis analysis.
  • Analysis of genes in the early secretory pathway in yeast.
  • High-throughput genomic data utilization.

Main Results:

  • A novel strategy for uncovering functional gene relationships was demonstrated.
  • The study successfully applied saturation epistasis analysis to yeast genetics.
  • Functional relationships within the early secretory pathway were elucidated.

Conclusions:

  • Saturation epistasis analysis is a powerful strategy for functional genomics.
  • High-throughput data can be effectively used to map gene function.
  • This approach provides a new framework for understanding complex biological pathways.