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The influence of mouse Ped gene expression on postnatal development
Adam Watkins1, Adrian Wilkins, Clive Osmond
1School of Biological Sciences, Developmental and Cell Biology Group, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. ajw7@soton.ac.uk
The Journal of Physiology
|November 5, 2005
Summary
The Ped gene influences preimplantation embryo development rate, affecting postnatal growth and cardiovascular function. Mice with slower development (Ped slow) showed increased body weight and higher blood pressure later in life.
Area of Science:
- Genetics
- Developmental Biology
- Physiology
Background:
- The Ped (preimplantation embryo development) gene encodes Qa-2 protein, influencing early embryonic development rates.
- A faster preimplantation development (Ped fast) phenotype is associated with Qa-2 protein expression, while its absence leads to a slower (Ped slow) phenotype.
Purpose of the Study:
- To investigate the impact of Ped gene expression on postnatal growth, systolic blood pressure, and organ allometry.
- To compare the physiological outcomes between mice with differing Ped gene expression levels.
Main Methods:
- Utilized two congenic mouse strains: B6.K1 (Ped slow; Qa-2 negative) and B6.K2 (Ped fast; Qa-2 positive).
- Monitored postnatal growth, measured systolic blood pressure at 21 weeks, and analyzed organ-to-body weight ratios.
Main Results:
- B6.K1 mice were lighter at birth but became heavier postnatally compared to B6.K2 mice.
- B6.K1 mice exhibited elevated systolic blood pressure and increased serum angiotensin-converting enzyme (ACE) activity.
- Altered organ:body weight ratios were observed, notably higher lung ratios in B6.K1 females.
Conclusions:
- Ped gene expression rate correlates with postnatal growth trajectories.
- Early embryonic development rate is associated with later-life cardiovascular function and ACE activity.
- Findings suggest a link between preimplantation development and adult physiological characteristics.