Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethical considerations in presymptomatic testing for variant CJD.

R E Duncan1, M B Delatycki, S J Collins

  • 1Murdoch Children's Research Institute and the Bruce Lefroy Centre for Genetic Health Research, Royal Children's Hospital, Parkville, Australia.

Journal of Medical Ethics
|November 5, 2005
PubMed
Summary

Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder with no current treatment. New diagnostic tests raise ethical questions about patient autonomy versus public health, proposing compulsory screening for high-risk individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Multiomics Blood-Based Biomarkers Predict Alzheimer's Predementia with High Specificity in a Multicentric Cohort Study" [The Journal of Prevention of Alzheimer's Disease 2024;11(3):567-581].

The journal of prevention of Alzheimer's disease·2025
Same author

Thy1c Cytology Is a Reliable Method of Excluding Thyroid Cancer in Dominant Cystic Nodules.

Cytopathology : official journal of the British Society for Clinical Cytology·2025
Same author

Are UV filters better together? A comparison of the toxicity of individual ultraviolet filters and off-the-shelf sunscreens to Daphnia magna.

Environmental pollution (Barking, Essex : 1987)·2024
Same author

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials.

The journal of prevention of Alzheimer's disease..·2024
Same author

Multiomics Blood-Based Biomarkers Predict Alzheimer's Predementia with High Specificity in a Multicentric Cohort Study.

The journal of prevention of Alzheimer's disease·2024
Same author

Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer's Continuum.

The journal of prevention of Alzheimer's disease·2023

Area of Science:

  • Neurodegenerative Diseases
  • Transmissible Spongiform Encephalopathies
  • Public Health Ethics

Background:

  • Variant Creutzfeldt-Jakob disease (vCJD) is a fatal, untreatable neurodegenerative disorder.
  • vCJD transmission is linked to bovine spongiform encephalopathy and human blood transfusions.
  • Presymptomatic diagnosis is crucial due to potential future epidemics.

Purpose of the Study:

  • To elaborate on the ethical implications of developing presymptomatic diagnostic tests for vCJD.
  • To compare vCJD testing ethics with predictive genetic testing for Huntington's disease and HIV screening.
  • To propose a testing paradigm balancing personal autonomy with societal protection.

Main Methods:

  • Ethical analysis of diagnostic test availability.
Keywords:
Health Care and Public Health

Related Experiment Videos

  • Comparative ethical framework with Huntington's disease and HIV screening.
  • Development of a proposed testing paradigm for vCJD.

    • Main Results:

    • The availability of reliable, non-invasive vCJD diagnostic tests presents significant ethical challenges.
    • Balancing individual autonomy with public health obligations is paramount.
    • A paradigm for vCJD testing is proposed, drawing parallels with HIV screening.

    Conclusions:

    • Compulsory testing of blood/organ donors and high-risk surgical patients is proposed.
    • The proposed paradigm includes unique features for vCJD screening.
    • Ethical considerations necessitate careful deliberation on who to test for vCJD.