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Related Experiment Videos

Oxidative stress and pulmonary function in the general population.

Heather M Ochs-Balcom1, Brydon J B Grant, Paola Muti

  • 1Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.

American Journal of Epidemiology
|November 5, 2005
PubMed
Summary

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Oxidative stress markers like TBARS were linked to reduced lung function (FEV1% and FVC%) in men, but not women. This suggests a potential gender difference in how oxidative stress impacts airflow limitation.

Area of Science:

  • Pulmonary Medicine
  • Biochemistry
  • Environmental Health

Background:

  • Oxidative stress is implicated in chronic airflow limitation.
  • Population-based evidence linking oxidative stress to pulmonary function is scarce.

Purpose of the Study:

  • To investigate the association between plasma oxidative stress markers and pulmonary function in a general population.
  • To explore potential gender differences in this association.

Main Methods:

  • Analysis of plasma thiobarbituric acid-reactive substances (TBARS), glutathione, glutathione peroxidase, and antioxidant capacity.
  • Assessment of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in 2,346 individuals.
  • Multivariate analysis adjusted for smoking status, pack-years, education, weight, and eosinophils.

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Main Results:

  • Inverse association found between TBARS and FEV1%/FVC% in men.
  • Positive association between glutathione peroxidase and FEV1%/FVC% in men.
  • Inverse association between glutathione and FEV1% in men.
  • No significant associations observed in women.
  • Associations in men remained significant after adjusting for serum carotenoids.

Conclusions:

  • Oxidative stress may be associated with airflow limitation in men.
  • Gender differences may exist in the relationship between oxidative stress and pulmonary function.