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Published on: March 6, 2018
Adjuvant systemic therapy for male breast carcinoma
Sharon H Giordano1, George H Perkins, Kristine Broglio
1Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. sgiordan@mdanderson.org
Cancer
|November 5, 2005
Summary
Men with breast carcinoma benefit from adjuvant systemic therapy, particularly hormonal therapy. This study highlights the positive impact of treatments like tamoxifen on survival rates in male breast cancer patients.
Area of Science:
- Oncology
- Endocrinology
Background:
- Male breast carcinoma is a rare condition.
- Adjuvant systemic therapy plays a role in treatment.
- M. D. Anderson Cancer Center experience is detailed.
Purpose of the Study:
- To evaluate the efficacy of adjuvant systemic therapy in male breast carcinoma patients.
- To identify the most beneficial treatment modalities.
Main Methods:
- Retrospective review of 135 male breast carcinoma patients treated between 1944 and 2001.
- Analysis of patient characteristics, adjuvant therapy, and outcomes.
- Statistical analysis including descriptive statistics and log rank test.
Main Results:
- Estrogen receptor-positive tumors were common (85%).
- Adjuvant hormonal therapy, primarily tamoxifen, significantly improved overall survival (HR 0.45; P = 0.01).
- Adjuvant chemotherapy showed a non-significant trend towards reduced mortality in lymph node-positive disease.
Conclusions:
- Male breast carcinoma patients benefit from adjuvant systemic therapy.
- Adjuvant hormonal therapy offers the greatest survival benefit.
- Further research into optimal systemic therapies for male breast cancer is warranted.
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