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Updated: Aug 15, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
New trends in synthesis of pyrazole nucleosides as new antimetabolites
Galal H Elgemeie1, Wafaa A Zaghary, Kamelia M Amin
1Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt.
Abstract:
Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.
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