Related Experiment Video
Updated: Aug 15, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Molecularly imprinted polymers for the enantioseparation of chiral drugs
1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. r.ansell@chem.leeds.ac.uk
Abstract:
Molecularly imprinted polymers have been applied for many years in chiral separations and increasingly have been applied to drugs. Separation speed and efficiency in methods such as HPLC and CEC are increasingly competitive with alternative established CSPs. The literature on separation of drug enantiomers using MIPs via HPLC, TLC, SFC and CEC are reviewed. Issues for method development, particularly the monomer-template interactions during the imprinting process, and the mechanism of solute retention on MIP CSPs in chromatography using normal phase or reverse-phase mobile phases are considered.
Related Concept Videos
Affinity Chromatography
Size-Exclusion Chromatography
Silica particles offer advantages such as rigidity,...
Prochirality
Stereoisomers
Molecules with Multiple Chiral Centers
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...

