Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SIR2 calls upon the ER.

Marc Tatar1

  • 1Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA.

Cell Metabolism
|November 8, 2005
PubMed
Summary
This summary is machine-generated.

Resveratrol extends lifespan in C. elegans by inhibiting SIR2, a protein that normally represses unfolded protein stress response genes. This suggests a novel mechanism for resveratrol

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular mechanisms and recent advances in cellular senescence.

Cell & bioscience·2026
Same author

Sandwich ELISA using newly generated monoclonal antibodies quantifies circulating neuropeptide F in Drosophila melanogaster.

Biochemical and biophysical research communications·2026
Same author

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.

JCI insight·2025
Same author

Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides.

Nature communications·2025
Same author

Glycogen synthase kinase 3β: a key player in progressive chronic kidney disease.

Clinical science (London, England : 1979)·2025
Same author

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan.

PLoS genetics·2025
Same journal

AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma.

Cell metabolism·2026
Same journal

Reactive species as regulators of immune cell metabolism, tolerance, and autoimmunity.

Cell metabolism·2026
Same journal

The interplay between the microbiome and immune cells in metabolic homeostasis and disease.

Cell metabolism·2026
Same journal

The metabolic basis of regulated cell death.

Cell metabolism·2026
Same journal

Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3.

Cell metabolism·2026
Same journal

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.

Cell metabolism·2026
See all related articles

Area of Science:

  • * Molecular biology
  • * Gerontology
  • * Stress response pathways

Background:

  • * Resveratrol is known to extend lifespan in model organisms like C. elegans.
  • * This longevity effect is traditionally attributed to the sirtuin 2 (SIR2) protein.
  • * Recent studies link resveratrol to the unfolded protein stress response (UPR) of the endoplasmic reticulum.

Purpose of the Study:

  • * To investigate the paradoxical relationship between resveratrol, SIR2, and UPR genes.
  • * To elucidate the mechanism by which resveratrol promotes longevity.
  • * To determine if resveratrol's lifespan-extending effects involve the modulation of SIR2's repressive activity on stress genes.

Main Methods:

  • * Utilized the model organism C.elegans.
  • * Analyzed gene expression related to the unfolded protein stress response.

Related Experiment Videos

  • * Investigated the role of SIR2 in mediating resveratrol's effects on lifespan and stress gene regulation.

    • Main Results:

    • * Resveratrol was confirmed to induce genes associated with the endoplasmic reticulum unfolded protein stress response.
    • * Paradoxically, SIR2 was found to repress these same stress-response genes.
    • * This indicates that resveratrol's pro-longevity action may stem from its ability to inhibit SIR2's repressive function.

    Conclusions:

    • * Resveratrol extends C. elegans lifespan through a mechanism involving the inhibition of SIR2.
    • * By inhibiting SIR2, resveratrol allows the induction of unfolded protein stress response genes.
    • * This provides a new perspective on how resveratrol impacts aging and stress resistance.