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Updated: Aug 15, 2026

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Non-culture-based analysis of bacterial populations from patients with chronic rhinosinusitis
Daniel A Power1, Jeremy P Burton, Chris N Chilcott
1Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Abstract:
Middle meatus aspirates from patients with chronic rhinosinusitis were analyzed by bacterial culture, denaturing gradient gel electrophoresis (DGGE), and antibiotic sensitivity techniques. DGGE detected a greater bacterial diversity than culture methods. Although resistance to antibiotics was low, there was evidence of changes in the composition of the bacterial microbiota over time, and the presence of noncultured bacteria was demonstrated.
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