Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hydrogen-bonding network in deacetylcephalothin.

Janusz Zachara1, Izabela D Madura, Andrzej Zimniak

  • 1Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland. janzac@ch.pw.edu.pl

Acta Crystallographica. Section C, Crystal Structure Communications
|November 8, 2005
PubMed
Summary

Structural analysis of deacetylcephalothin reveals its central bicyclic moiety geometry is similar to other cephalosporin antibiotics. Molecules form helical chains and layers stabilized by hydrogen bonds, offering insights into antibiotic structure-activity relationships.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing Febuxostat Solubility Through Cocrystal Formation: Role of Substrate Selection and Amide Coformers.

International journal of molecular sciences·2025
Same author

An experimental and computational investigation of the cyclopentene-containing peptide-derived compounds: focus on pseudo-cyclic motifs via intramolecular interactions.

Royal Society open science·2024
Same author

Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines.

Molecular diversity·2023
Same author

Hydrogen-Bonding Motifs in Adducts of Allylamine with the 10 Simplest <i>n</i>-Alcohols: Single-Crystal X-ray Diffraction Studies and Computational Analysis.

Crystal growth & design·2022
Same author

Structural and Biofunctional Insights into the Cyclo(Pro-Pro-Phe-Phe-) Scaffold from Experimental and In Silico Studies: Melanoma and Beyond.

International journal of molecular sciences·2022
Same author

Copper-catalyzed direct C-H arylselenation of 4-nitro-pyrazoles and other heterocycles with selenium powder and aryl iodides. Access to unsymmetrical heteroaryl selenides.

RSC advances·2022

Area of Science:

  • Crystallography and Molecular Modeling
  • Medicinal Chemistry
  • Biochemistry

Background:

  • Cephalosporin antibiotics are crucial in treating bacterial infections.
  • Understanding the structural basis of their activity is key to developing new drugs.
  • Deacetylcephalothin is a derivative with potential biological relevance.

Purpose of the Study:

  • To determine the crystal structure of deacetylcephalothin.
  • To analyze the molecular geometry and intermolecular interactions.
  • To compare its structure to other biologically active cephalosporins.

Main Methods:

  • Single-crystal X-ray diffraction analysis.
  • Analysis of bond lengths, angles, and torsion angles.
  • Identification of hydrogen bonding networks and crystal packing.

Related Experiment Videos

Main Results:

  • The central bicyclic moiety of deacetylcephalothin exhibits geometry similar to known cephalosporin antibiotics.
  • Molecules self-assemble into helical chains via O-H...O hydrogen bonds.
  • These helices form infinite layers stabilized by N-H...O interactions.
  • Further stabilization is provided by O-H...S and C-H...O hydrogen bonds.

Conclusions:

  • The determined structure of deacetylcephalothin is consistent with the general structural features of active cephalosporins.
  • The observed supramolecular architecture highlights the role of hydrogen bonding in stabilizing the crystal lattice.
  • This structural information can inform the design of novel cephalosporin analogs with improved therapeutic properties.