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[Treatment of adynamic bone disease with the complete replacement from calcium carbonate to sevelamer hydrochloride]

Toru Hyodo1, Haruki Wakai, Toru Takemura

  • 1Dialysis center, Yokohama Dai-ichi Hospital.

Clinical Calcium
|November 8, 2005
PubMed

Insights

Sevelamer hydrochloride effectively treats adynamic bone disease in hemodialysis patients, improving bone turnover. However, careful monitoring is needed to prevent osteitis fibrosa development.

Area of Science:

  • Nephrology
  • Bone Metabolism
  • Pharmacology

Context:

  • Adynamic bone disease (ABD) is a common complication in maintenance hemodialysis (HD) patients.
  • Traditional treatments for ABD have limitations.
  • The study investigates a novel therapeutic approach for ABD in HD patients.

Purpose:

  • To evaluate the therapeutic efficacy of sevelamer hydrochloride (SH) in inducing hypocalcemic stimulation for treating adynamic bone disease (ABD).
  • To assess the changes in bone turnover markers in HD patients undergoing SH treatment.
  • To identify potential adverse effects associated with SH administration for ABD.

Summary:

  • Twenty-eight maintenance hemodialysis patients with ABD were treated with sevelamer hydrochloride (SH).
  • Patients initially received calcium carbonate (CC) and SH, transitioning to SH monotherapy.
  • Bone turnover was assessed using intact-osteocalcin (iOC) levels at baseline, 6, and 12 months.
  • At 12 months, 32.1% of patients achieved normal bone turnover (NTB), while 3.6% developed osteitis fibrosa.

Impact:

  • Sevelamer hydrochloride shows promise as an effective treatment for adynamic bone disease in hemodialysis patients.
  • The study highlights the potential for SH to improve bone metabolism and normalize bone turnover.
  • Caution is advised regarding the risk of developing osteitis fibrosa, necessitating careful patient monitoring.

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