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Updated: Aug 15, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

[Aspergillus bronchitis and aspergilloma treated successfully with voriconazole]

N Freymond1, J-B Le Loch, G Devouassoux

  • 1Service de Pneumologie et d'Immunologie Clinique, Centre Hospitalier Lyon Sud, Pierre Bénite, France. nathalie.freymond@chu-lyon.fr

Revue Des Maladies Respiratoires
|November 8, 2005
PubMed
Abstract

Insights

This case report highlights voriconazole as an effective treatment for pulmonary aspergilloma and aspergillus bronchitis, common fungal lung infections. The study shows significant improvement in a patient with these conditions.

Area of Science:

  • Mycology
  • Pulmonology
  • Infectious Diseases

Background:

  • Aspergillus fumigatus is a common soil fungus causing lung infections like aspergilloma and aspergillus bronchitis.
  • These conditions can occur together, particularly in cystic fibrosis patients.

Observation:

  • A 57-year-old patient with diffuse bronchiectasis presented with both aspergilloma and aspergillus bronchitis.
  • The aspergilloma complicated a lung cavity caused by atypical mycobacterial infection.

Findings:

  • Treatment with voriconazole for one month led to a reduction in aspergilloma size.
  • Endobronchial changes associated with aspergillus bronchitis resolved after voriconazole therapy.

Implications:

  • Voriconazole demonstrates potential as a novel therapeutic option for aspergilloma and aspergillus bronchitis.
  • This expands its utility beyond invasive aspergillosis treatment.

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