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Anaplastic large cell lymphoma: a unique presentation with urinary bladder involvement: a case report
Amanda J Murphy1, Paul O'Neill, Frank O'Brien
1Department of Cellular Pathology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
International Journal of Surgical Pathology
|November 8, 2005
Summary
Anaplastic large cell lymphoma (ALCL), a rare T-cell cancer, can present with unusual urinary bladder symptoms. This case highlights a 28-year-old man with ALCL and bladder involvement, emphasizing its rarity.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell lymphoma.
- Extranodal involvement is common in systemic ALCL, but urinary bladder presentation is exceptionally rare.
Observation:
- A 28-year-old male presented with hematuria, dysuria, and lower abdominal pain.
- Imaging revealed pelvic lymphadenopathy and a thickened bladder wall.
- Bladder biopsies confirmed diffuse infiltration by large pleomorphic cells.
Findings:
- Immunohistochemistry showed CD30 and epithelial membrane antigen staining.
- The findings confirmed systemic ALCL with bladder infiltration.
- This represents the first documented case of ALCL presenting with bladder symptoms.
Implications:
- This case expands the understanding of ALCL's extranodal manifestations.
- Highlights the importance of considering ALCL in differential diagnoses for unexplained bladder symptoms.
- Suggests potential for urinary tract symptoms in systemic ALCL presentations.