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Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors
1ITI Research Institute, University of Bern, CH-3010 Bern, Switzerland.
Abstract:
FGFRL1 is a novel member of the FGF receptor family. It is expressed at very low levels in a great variety of cell lines and at relatively high levels in SW1353 chondrosarcoma cells, MG63 osteosarcoma cells and A204 rhabdomyosarcoma cells. Screening of 241 different human tumors with the help of a cancer profiling array suggested major alterations in the relative expression of FGFRL1 in ovarian tumors. Five distinct ovary tumors were therefore analyzed by quantitative and competitive PCR. Several tumors were found to exhibit a significant decrease in the expression of FGFRL1 in the tumor tissue relative to the matched control tissue. One ovarian tumor showed a 25-fold increase in the relative expression. Since FGFRL1 appears to be involved in the control of cell proliferation and differentiation, its aberrant expression might contribute to the development and progression of ovarian tumors.
Insights
Fibroblast Growth Factor Receptor Like 1 (FGFRL1) shows altered expression in ovarian tumors. Aberrant FGFRL1 levels may play a role in ovarian cancer development and progression.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Fibroblast Growth Factor Receptor Like 1 (FGFRL1) is a novel member of the FGF receptor family.
- FGFRL1 exhibits low expression in most cell lines but is highly expressed in specific sarcoma cell lines.
Purpose of the Study:
- To investigate the expression levels of FGFRL1 in various human tumors, with a focus on ovarian tumors.
- To determine if alterations in FGFRL1 expression are associated with ovarian cancer development.
Main Methods:
- Screening of 241 human tumors using a cancer profiling array.
- Quantitative and competitive PCR analysis of FGFRL1 expression in five distinct ovarian tumors and matched control tissues.
Main Results:
- Screening identified significant alterations in FGFRL1 relative expression in ovarian tumors.
- Quantitative analysis revealed decreased FGFRL1 expression in several ovarian tumors compared to controls.
- One ovarian tumor exhibited a substantial 25-fold increase in FGFRL1 expression.
Conclusions:
- Aberrant expression of FGFRL1 is observed in ovarian tumors.
- FGFRL1's potential role in cell proliferation and differentiation suggests its aberrant expression may contribute to ovarian tumor development and progression.
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