Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behçet's disease: familial clustering and immunogenetics.

P Fietta1

  • 1Osteo-Articular Department, Rheumatic Disease and Internal Medicine Unit, Hospital of Parma, Italy. farnese15@libero.it

Clinical and Experimental Rheumatology
|November 9, 2005
PubMed
Summary

Behçet's disease (BD) is a multisystemic inflammatory disorder with genetic predispositions. Familial clustering suggests strong immunogenetic influences, particularly in childhood cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is exophthalmos a localizing symptom of a brain tumor?

Confinia neurologica·2010
Same author

Hematologic manifestations of connective autoimmune diseases.

Clinical and experimental rheumatology·2009
Same author

Mondor's disease and polymyalgia rheumatica: a case report.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2006
Same author

Hematologic manifestations of primary Sjögren's syndrome.

Clinical and experimental rheumatology·2006
Same author

Respiratory system involvement in systemic vasculitides.

Clinical and experimental rheumatology·2006
Same author

Childhood onset of psoriatic onycho-pachydermo-periostitis (POPP).

Journal of the European Academy of Dermatology and Venereology : JEADV·2005

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Behçet's disease (BD) is a relapsing, multisystemic inflammatory disorder.
  • Key symptoms include orogenital ulcerations, eye, and skin lesions, with potential involvement of various organ systems.
  • Vasculitis is the primary histopathologic feature, sometimes complicated by thrombosis.

Purpose of the Study:

  • To review available reports on Behçet's disease familial clustering.
  • To examine the evidence for immunogenetic predisposing factors in BD pathogenesis.
  • To explore the role of genetic background and environmental factors in BD.

Main Methods:

  • Review of existing literature on Behçet's disease familial aggregation.
  • Analysis of studies investigating human leukocyte antigen B*51 association.
  • Examination of genetic polymorphisms in host effector molecules and prothrombotic factors.

Main Results:

  • Behçet's disease shows strong familial aggregation, indicating a significant genetic contribution.
  • Association with human leukocyte antigen B*51 is a hallmark across ethnic groups.
  • Familial clustering exhibits genetic anticipation and higher prevalence in childhood, suggesting immunogenetic influences.

Conclusions:

  • Behçet's disease pathogenesis likely involves a unique immune response in genetically predisposed individuals.
  • Genetic factors, including familial aggregation and specific HLA associations, play a crucial role.
  • Further research is needed to clarify the contribution of various genetic polymorphisms to BD susceptibility and thrombosis.

Related Experiment Videos