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Updated: Aug 15, 2026
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
Published on: February 1, 2020
[Clinicopathological study of lymphatic vessel density and distribution in pancreatic cancer]
Gang Jin1, Xian-gui Hu, Rui Liu
1Department of General Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China. Jingang@sh163.net
Objective:
To clarify the clinicopathological significance of lymphatic vessel density (LVD) and distribution in pancreatic cancer.
Methods:
We measured LVD in 43 pancreatic cancer specimens by immunostaining with specific lymphatic endothelium marker, and examined their relationship with well-defined clinicopathological variables.
Results:
Intratumoral LVD (9.4 +/- 10.0) was significantly lower than periturmoral (16.0 +/- 9.7) (P < 0.001) and nontumoral LVD (13.5 +/- 6.0) (P < 0.01). Increased peritumoral LVD correlated significantly with tumor staging (P < 0.05) and lymph node involvement (P < 0.05).
Conclusion:
The lymphatic vessels distribution in pancreatic cancer samples and peritumoral lymphangiogenesis may promote the malignant progression and lymph node metastasis of pancreatic cancer.
