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Updated: Aug 15, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Relationship between endothelial function in the coronary and brachial arteries

Hiroki Teragawa1, Kentaro Ueda, Keiji Matsuda

  • 1Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan. hteraga@hiroshima-u.ac.jp

Clinical Cardiology
|November 9, 2005
PubMed

Insights

Peripheral and coronary endothelial function are linked in patients with normal coronary arteries. This suggests that endothelial dysfunction may affect both systems concurrently, impacting atherosclerosis development.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Imaging

Background:

  • Endothelial dysfunction initiates atherosclerosis.
  • Correlation between coronary and peripheral arterial endothelial function is not well understood.

Purpose of the Study:

  • To investigate the relationship between coronary and peripheral endothelial function.

Main Methods:

  • Assessed brachial artery endothelial function using high-resolution ultrasonography.
  • Measured coronary artery diameter and coronary blood flow (CBF) via quantitative angiography and Doppler flow velocity during acetylcholine and nitroglycerin infusion.
  • Analyzed changes in vascular parameters in response to drug administration in 41 patients with normal coronary arteries.

Main Results:

  • Brachial artery flow-mediated dilation (FMD) positively correlated with coronary artery diameter changes and CBF.
  • Multivariate analysis indicated FMD is associated with coronary vascular responses to acetylcholine.
  • Results highlight a significant link between peripheral and coronary endothelial function.

Conclusions:

  • Brachial artery endothelial function is associated with coronary endothelial function in patients with angiographically normal coronary arteries.
  • Endothelial dysfunction may manifest simultaneously in both coronary and peripheral arteries.
  • Findings suggest potential for early detection and intervention for systemic endothelial dysfunction.
Abstract

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