Chemotherapy for low-grade gliomas

Low-grade gliomas pose a difficult problem for the neuro-oncologist. More needs to be known about their natural history. In addition, the role and timing of radiotherapy and chemotherapy in the management of low-grade tumors is highly controversial. Most agree that physicians should recommend treatment in symptomatic cases or in instances of radiologic tumor progression. This review discusses some of the recent advances with respect to chemotherapy for low-grade gliomas, with a special emphasis on low-grade astrocytomas and oligodendrogliomas.