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Correlation between human papillomavirus infection and bladder transitional cell carcinoma
M R Barghi1, A Hajimohammadmehdiarbab, S M M Hosseini Moghaddam
1Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Urology and Nephrology Research Center, Tehran, Iran. h_sasan@hotmail.com
BMC Infectious Diseases
|November 9, 2005
Summary
Human papillomavirus (HPV) infection is linked to bladder cancer. This study found HPV DNA in 35.6% of transitional cell carcinoma cases, suggesting a potential role in cancer development.
Area of Science:
- Oncology
- Virology
- Urology
Background:
- Transitional cell carcinoma (TCC) is the most common type of bladder cancer.
- The role of human papillomavirus (HPV) in TCC etiology is under investigation.
Purpose of the Study:
- To investigate the association between HPV infection and transitional cell carcinoma of the bladder.
Main Methods:
- Polymerase chain reaction (PCR) was used to detect HPV DNA.
- Fifty-nine bladder TCC tissue samples were compared with 20 non-neoplastic bladder tissue samples.
Main Results:
- HPV DNA was detected in 35.6% of TCC samples versus 5% in controls (P = 0.008).
- HPV18 was the predominant type, found in 81% of positive TCC samples.
- No significant differences in age or sex were observed between groups.
Conclusions:
- HPV infection may play a causative role in the development of transitional cell carcinoma of the bladder.
- Further research is warranted to confirm the role of HPV in bladder cancer.