Related Experiment Video

Updated: Aug 15, 2026

Experimental Human Pneumococcal Carriage
07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

Haemophilus influenzae type b carriage among 3- to 24-month-old Turkish children

S Poyrazoglu1, S Kömeç, G Gökçay

  • 1Istanbul University, Istanbul Faculty of Medicine, Department of Paediatrics, Istanbul, Turkey. sukranpoyrazoglu@yahoo.com

Epidemiology and Infection
|November 9, 2005
PubMed

Insights

Oropharyngeal Haemophilus influenzae (Hib) colonization was studied in Turkish children under two. Breastfeeding and passive smoking influenced Hib carriage, with significant antimicrobial resistance observed.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Epidemiology

Background:

  • Limited data exists on Haemophilus influenzae (Hib) epidemiology in developing countries.
  • Understanding Hib colonization and resistance is crucial for public health interventions.

Purpose of the Study:

  • To determine the prevalence of oropharyngeal Hib colonization in Turkish children under two years old.
  • To identify antimicrobial resistance patterns of Hib isolates in this population.

Main Methods:

  • A cross-sectional study involving 818 healthy children.
  • Oropharyngeal secretions were collected for Hib carriage analysis.
  • Antimicrobial susceptibility testing was performed on isolated H. influenzae strains.

Main Results:

  • The overall Hib carriage rate was 7.2%, increasing with age.
  • Hib carriage was higher than expected in 3- to 6-month-olds and associated with passive smoking.
  • Breastfeeding status was a significant factor for colonization (OR 2.2).
  • High resistance rates were found for trimethoprim-sulphamethoxazole (51.8%) and ampicillin (21.4%).
  • No resistance to ceftriaxone was observed.

Conclusions:

  • Breastfeeding and passive smoking are key factors influencing Hib colonization in young Turkish children.
  • Significant antimicrobial resistance necessitates careful antibiotic selection for Hib infections.
  • Ceftriaxone remains a reliable treatment option against H. influenzae in this region.

More Related Videos

Assessing Respiratory Immune Responses to Haemophilus Influenzae06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...