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Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint
Erdinc Aydin1, Sina Uckan, B Handan Ozdemir
1Department of Otorhinolaryngology, Faculty of Medicine, Baskent University, Ankara, Turkey. erdinca@baskent-ank.edu.tr
Objective:
To evaluate influence of mitomycin C on fibrosis in temporomandibular joints of rabbits with mandibular traction.
Study Design:
Twenty rabbits (8 control, 12 mitomycin C group) were included. Titanium screws were placed in the anterior edge of the right masseter tuberosity and the posterior part of the right zygoma. Elastic bands were placed between 2 screws to initiate posterio-superior displacement of the mandible to the right. Animals in the control group (CG) received intraarticular NaCl (0.9%) on the nondrawing (left) side, and animals in the study group (SG) received mitomycin C weekly (0.4 mg/mL) for 6 weeks. Rabbits were decapitated, temporomandibular joints were removed, and histopathological investigation was performed.
Results:
Microscopically, 4 of 6 rabbits in the CG had fibrosis in the temporomandibular joint, whereas only 1 of 11 rabbits in the SG had fibrosis (P < 0.05).
Conclusion:
Application of mitomycin C to the temporomandibular joint of rabbits significantly reduces formation of intraarticular fibrous adhesions.
Significance:
This is the first study in the literature investigating the use of mitomycin C in the joints.
Ebm Rating:
B-2.
