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Related Experiment Videos

Salivary cortisol and memory function in human aging.

Ge Li1, Monique M Cherrier, Debby W Tsuang

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. gli@u.washington.edu

Neurobiology of Aging
|November 9, 2005
PubMed
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High salivary cortisol levels in older adults are linked to impaired memory and executive function. Elevated evening cortisol specifically predicts future memory decline over three years.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Gerontology

Background:

  • Elevated glucocorticoids, like cortisol, are implicated in hippocampal changes and cognitive impairment.
  • Previous research suggests a link between high cortisol concentrations and reduced cognitive function.

Purpose of the Study:

  • To investigate the association between salivary cortisol levels and cognitive changes over three years in older adults.
  • To determine if baseline cortisol levels predict future cognitive decline.

Main Methods:

  • Salivary cortisol was measured annually at 08:00, 15:00, and 23:00h in 79 cognitively intact older adults (mean age 78).
  • Cognitive function, including declarative memory and executive function, was assessed annually over three years.

Main Results:

Related Experiment Videos

  • Higher mean cortisol levels and elevated 23:00h cortisol were associated with poorer performance on memory and executive function tasks.
  • In subjects completing the study, higher initial 23:00h cortisol predicted a decline in delayed paragraph recall over three years.

Conclusions:

  • High salivary cortisol is associated with impaired declarative memory in non-demented older individuals.
  • Elevated evening cortisol concentrations may predict future memory decline in older adults.