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Related Experiment Videos

The pattern electroretinogram in glaucoma and ocular hypertension.

E O'Donaghue1, G B Arden, F O'Sullivan

  • 1Electrodiagnosis Department, Moorfields Eye Hospital, London.

The British Journal of Ophthalmology
|July 1, 1992
PubMed
Summary

Pattern electroretinography (PERG) effectively identifies glaucoma and detects abnormalities in high-risk ocular hypertensive eyes. This diagnostic tool shows greater abnormality in treated glaucoma and correlates with clinical disease severity.

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Neuro-ophthalmology (Aeolus Press)·2020

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Clinical Diagnostics

Background:

  • Glaucoma is a progressive optic neuropathy characterized by vision loss.
  • Ocular hypertension (OHT) is a risk factor for glaucoma development.
  • Early detection of glaucoma and risk stratification in OHT are crucial.

Purpose of the Study:

  • To evaluate the efficacy of pattern electroretinography (PERG) in diagnosing established glaucoma.
  • To assess PERG for detecting subclinical abnormalities in ocular hypertensive (OHT) eyes.
  • To correlate PERG findings with clinical parameters and treatment status.

Main Methods:

  • Longitudinal study (up to 2 years) involving eyes with established glaucoma, high/medium/low risk OHT, and normal controls.
  • Clinical examination and pattern electroretinography (PERG) were performed in a masked fashion.

Related Experiment Videos

  • Development of criteria to differentiate glaucomatous, OHT, and control eyes using PERG.

    • Main Results:

    • PERG criteria successfully distinguished established glaucomatous eyes from normal controls.
    • Abnormalities detected by PERG were present in some OHT eyes, notably those at high risk.
    • PERG abnormalities were most pronounced in treated glaucoma eyes and correlated with clinical severity.

    Conclusions:

    • Pattern electroretinography is a valuable tool for diagnosing glaucoma and identifying at-risk OHT individuals.
    • PERG demonstrates functional deficits in eyes with OHT, particularly those with higher risk factors.
    • The low test-retest variability of PERG supports its reliability for clinical application.