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Published on: April 5, 2011
Severe ataxia caused by amiodarone
Daniel G Krauser1, Alan Z Segal, Paul Kligfield
1Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University and the Cornell Campus of The New York-Presbyterian Hospital, New York, NY, USA.
Abstract:
Neurologic toxicity is an infrequently reported and under-recognized consequence of amiodarone, symptoms of which may include tremor, peripheral sensorimotor neuropathy, proximal weakness, and ataxia. The investigators report the rapid and complete remission of 4 months of progressively debilitating ataxia with the discontinuation of small-dose amiodarone in an elderly woman with hypertrophic obstructive cardiomyopathy and paroxysmal atrial fibrillation. Despite the long half-life of amiodarone, her symptoms began to reduce after several days, and she was walking without assistance within 1 week. Wider recognition of this syndrome may avoid unnecessary and lengthy diagnostic evaluation and promote earlier neurologic recovery.
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