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Cancer and cardiovascular disease after vasectomy: an epidemiological database study
Michael J Goldacre1, Clare J Wotton, Valerie Seagroatt
1Department of Public Health, University of Oxford, Oxford, United Kingdom. michael.goldacre@dphpc.ox.ac.uk
Objective:
To determine whether vasectomy is associated with an increased long-term risk of cancer or cardiovascular disease.
Design:
Analysis of database of linked statistical records of hospital admissions and deaths.
Setting:
Health region in southern England.
Patient(S):
Men aged 20-59 years who were admitted to a hospital for vasectomy.
Intervention(S):
None.
Main Outcome Measure(S):
Rates of cancer and cardiovascular disease compared with the corresponding rates in a reference cohort, expressed as a rate ratio.
Result(S):
We found no elevation of risk, after vasectomy, of prostate cancer (rate ratio 0.74, 95% confidence interval [CI] 0.45-1.14) or other cancers. The rate ratio for coronary heart disease overall after vasectomy was 0.95 (95% CI 0.88-1.02); and the rate ratio > or =20 years after vasectomy was 0.98 (95% CI 0.80-1.19).
Conclusion(S):
Our findings add to the evidence that vasectomy is not associated with an increase in the long-term risk of these diseases.
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