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Plasma catecholamines: follow-up on 10-year study in health and cardiovascular disease

P Prikryl1, G Cornélissen, K Otsuka

  • 1Masaryk University, Brno, Czech Republic.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 9, 2005
PubMed

Insights

Circannual rhythms of blood pressure, heart rate, and catecholamines were analyzed. Elevated epinephrine and norepinephrine levels predicted cardiovascular disease mortality in angina patients over a decade before death.

Area of Science:

  • Chronobiology
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Cardiovascular diseases (CVD) remain a leading cause of mortality globally.
  • Understanding predictive biomarkers for CVD development and prognosis is crucial for early intervention.
  • Circannual rhythms, or yearly biological cycles, may influence physiological parameters and disease risk.

Purpose of the Study:

  • To investigate the predictive value of blood pressure (BP), heart rate (HR), and catecholamines (epinephrine and norepinephrine) for subsequent cardiovascular disease.
  • To assess circannual variation in these physiological parameters across different patient groups.
  • To identify potential biomarkers for predicting mortality in patients with angina pectoris.

Main Methods:

  • Longitudinal study measuring systolic and diastolic BP, HR, epinephrine (E), and norepinephrine (NE) in healthy subjects, essential hypertension patients, and angina pectoris patients.
  • Measurements were taken thrice annually in 1980, 1984, and 1989.
  • Single cosinor analysis assessed individual circannual rhythms, with population-mean cosinor summarizing group data. Parameter tests compared rhythm characteristics.

Main Results:

  • A significant circannual rhythm was consistently demonstrated across all groups (P < 0.05).
  • Differences in MESOR (midline estimating statistic of rhythm) and/or circannual amplitude were observed among the groups.
  • Patients with angina pectoris who later died showed distinct epinephrine and norepinephrine profiles compared to all other groups, detectable over 10 years prior to mortality. BP and HR did not show similar predictive separation.

Conclusions:

  • Circannual rhythms of physiological parameters are present in healthy individuals and patients with cardiovascular conditions.
  • Catecholamine levels, specifically epinephrine and norepinephrine, exhibit predictive value for cardiovascular mortality in angina patients, outperforming BP and HR.
  • These findings suggest that chronobiological assessment of catecholamines may offer a novel approach for early risk stratification in cardiovascular disease.

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